This appointment is to work within the laboratory of Professor Griffin and will focus on the development of chemical biology and proteomic approaches to understanding protein structure function. The principle focus will be development and application of hydrogen/deuterium exchange (HDX) and cross-linking (XL) mass spectrometry to aid in understanding the mechanism of activation of receptors by ligands, PTMs and coregulatory interactions. The candidate is expected to contribute to all aspects of the project including cloning, expression and purification of target proteins, as well as operation of the mass spectrometry platforms (automation, chromatography, mass spectrometry and data processing). The candidate will also be involved in functional studies involving genomic screens and mutagenesis.
About The Scripps Research Institute
The Scripps Research Institute, one of the world's largest, private, non-profit research organizations, stands at the forefront of basic biomedical science, a vital segment of medical research that seeks to comprehend the most fundamental processes of life. Over the last decades, the institute has established a lengthy track record of major contributions to the betterment of health and the human condition.