We are seeking a highly talented and motivated individual with a strong background in synthetic organic chemistry to join our medicinal chemistry program as a postdoctoral associate in the department of Molecular Medicine at The Scripps Research Institute. We are seeking to develop and optimize S1PR3-selective ligands with improved potency, selectivity and pharmacokinetic properties. Current S1P receptor ligands will be optimized for potency and functional selectivity for S1PR3 versus other S1P receptor family members; S1P1, S1P2, S1P4 and S1P5. Physicochemical properties of S1PR3 selective compounds including microsome stability, solubility, total polar surface area and pharmacokinetics properties will be optimized for in vivo use.
About The Scripps Research Institute
The Scripps Research Institute, one of the world's largest, private, non-profit research organizations, stands at the forefront of basic biomedical science, a vital segment of medical research that seeks to comprehend the most fundamental processes of life. Over the last decades, the institute has established a lengthy track record of major contributions to the betterment of health and the human condition.