This appointment is to work within the laboratory of Professor Sundrud and will focus on the local regulation of mucosal T cell function by bile acids in the small intestine. The Sundrud lab has recently demonstrated that circulating T cells sense and respond to the presence of locally-reabsorbed bile acids in the ileum to maintain homeostasis and suppress the development of small bowel inflammatory disease (PMID: 29262351); the lab has new R01-level funding to explore the T cell-intrinsic functions of ligand-operated nuclear receptors in T cell-bile acid cross-talk in the intestine.

The successful candidate will contribute to all aspects of the project, including both in vitro and in vivo T cell analyses, molecular cloning, retroviral T cell transduction experiments, as well as execution and analysis of high-content flow cytometry, RNA-seq, DNA-seq and ATAC-seq experiments.

The successful candidate will work in a fast-paced and dynamic group environment and will be supported by a full-time Senior Research Assistant.

For more information about the Sundrud lab, please visit www.sundrudlab.com.

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